Aphids display an abundance of adaptations that are not easily studied in existing model systems. Here we review the biology of a new genomic model system, the pea aphid, Acyrthosiphon pisum. We then discuss several phenomena that are particularly accessible to study in the pea aphid: the developmental genetic basis of polyphenisms, aphid–bacterial symbioses, the genetics of adaptation and mechanisms of virus transmission. The pea aphid can be maintained in the laboratory and natural populations can be studied in the field. (...) These properties allow controlled experiments to be performed on problems of direct relevance to natural aphid populations. Combined with new genomic approaches, the pea aphid is poised to become an important model system for understanding the molecular and developmental basis of many ecologically and evolutionarily relevant problems. BioEssays 28: 747–755, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

La discussion sur le langage privé que l’on trouve dans les Recherchesphilosophiques a été écrite entre 1937 et 1945, après que les 190 premières remarques de la partie I du livre eurent presque atteint leur forme finale. Les textes post-1936 sur le langage privé constituent un nouveau départ, dans sa lettre et son esprit, par rapport au matériau d’avant 1936.Néanmoins, entre 1929 et 1936, Wittgenstein s’est penché à plusieurs reprises sur l’idée d’un langage « que moi seul peux comprendre ». (...) Un volet de cette question qui, lui, est abordé directement dans les Recherches, c’est l’idée que « si j’appliquais le mot “douleur” uniquement à ce que j’ai nommé jusqu’ici “ma douleur”, et les autres “la douleur de L.W.”, je ne ferais ainsi aucun tort aux autres, si toutefois l’on avait prévu une notation qui d’une façon ou d’une autre, permettrait de pallier l’absence du mot “douleur” dans d’autres combinaisons ». Cependant, la discussion de cette question dans les Recherches est beaucoup plus brève que dans les textes d’avant 1936. J’examine le rapport entre ce § 403 des Recherches d’un côté, et de l’autre côté les textes des cahiers de 1929 et les Remarques philosophiques , en retraçant le développement initial de cette argumentation et en explorant les principales lignes de continuité et de discontinuité dans le traitement que Wittgenstein réserve à la question du langage privé.The discussion of private language in the Investigations was written between 1937 and 1945, after the first 190 remarks of Part I of the book had almost reached their final form. The post-1936 writing on private language represents a fresh start, both in wording and in conception, on the pre-1936 material.Nevertheless, Wittgenstein did repeatedly discuss the idea of a language which “only I myself can understand” during 1929-36. One strand in this discussion that is directly taken up in the Investigations is the idea that “If I were to reserve the word ‘pain’ solely for what I had hitherto called ‘my pain”, and others “L.W.’s pain,” I should do other people no injustice, so long as a notation were provided in which the loss of the word ‘pain’ in other connexions were somehow supplied.” However, the discussion of this topic in the Investigations is much briefer than in the pre-1936 writing. I look at the relationship between §403 and texts from the 1929 notebooks and the Philosophical Remarks, assembled in the spring of 1930, mapping out the earlier development of this line of argument and exploring the principal continuities and discontinuities in Wittgenstein’s treatment of private language. (shrink)

Drawing on ten years of research on the unpublished Wittgenstein papers, Stern investigates what motivated Wittgenstein's philosophical writing and casts new light on the Tractatus and Philosophical Investigations. The book is an exposition of Wittgenstein's early conception of the nature of representation and how his later revision and criticism of that work led to a radically different way of looking at mind and language. It also explains how the unpublished manuscripts and typescripts were put together and why they often (...) provide better evidence of the development of his ideas than can be found in his published writing. In doing so, the book traces the development of a number of central themes in Wittgenstein's philosophy, including his conception of philosophical method, the picture theory of meaning, the limits of language, the application of language to experience, his treatment of private language, and what he called the "flow of life." Arguing that Wittgenstein's views are often much more simple (and more radical) than we have been led to believe, Wittgenstein on Mind and Language provides an overview of the development of Wittgenstein's philosophy and brings to light aspects of his philosophy that have been almost universally neglected. (shrink)

Criticized as a nostalgic anachronism by those who oppose her version of political theory and lauded as symbol of direct democratic participation by those who favor it, the Athenian polis features prominently in Hannah Arendt's account of politics. This essay traces the origin and development of Arendt's conception of the polis as a space of appearance from the early 1950s onward. It makes particular use of the Denktagebuch, Arendt's intellectual diary, in order to shed new light on the historicity of (...) one of her central concepts. The article contends that both critics and partisans of Arendt's use of the polis have made the same mistake: they have presumed that the polis represents a space of face-to-face immediacy. In fact, Arendt compared the polis to a series of analogues, many of which are not centered on direct exchanges between political actors and spectators. As a result, Arendt's early work on the polis turns out to anticipate many of the concerns of her later work on judgment, and her theory of the polis becomes a theory of topics. (shrink)

Extreme variation in the meaning of the term “species” throughout the history of biology has often frustrated attempts of historians, philosophers and biologists to communicate with one another about the transition in biological thinking from the static species concept to the modern notion of evolving species. The most important change which has underlain all the other fluctuations in the meaning of the word “species” is the change from it denoting such metaphysical entities as essences, Forms or Natures to denoting classes (...) of individual organisms. Several authors have taken notice of the role of metaphysics in the work of particular biologists. An attempt will be made in this paper to present a systematic investigation of the role which metaphysics has played in the work of representative biologists throughout the history of biology, especially as it relates to their species concepts. (shrink)

Biological species have been treated traditionally as spatiotemporally unrestricted classes. If they are to perform the function which they do in the evolutionary process, they must be spatiotemporally localized individuals, historical entities. Reinterpreting biological species as historical entities solves several important anomalies in biology, in philosophy of biology, and within philosophy itself. It also has important implications for any attempt to present an "evolutionary" analysis of science and for sciences such as anthropology which are devoted to the study of single (...) species. (shrink)

The title of this chapter is borrowed from John McDowell's ‘One strand in the private language argument’ (1998b). In that paper, he argues that much of what is best in Wittgenstein's discussion of private language can be seen as a development of the Kantian insight that there is no such thing as an unconceptualized experience - that even the most elementary sensation must have a conceptual aspect. On McDowell's view, a sensation is a ‘perfectly good something - an object, if (...) you like, of concept involving awareness. What is a nothing … is the supposed pre-conceptual this that is supposed to ground our conceptualizations’ (1998b: 283). McDowell's Sellarsian objections to the notion of the Given in that paper are an insightful and illuminating development of Wittgenstein's discussion of the topic. However, McDowell's recoil from the notion of an unconceptualized experience, a conception of sensation on which it turns out to be ‘simply a nothing’ (ibid.), leads him to reject Wittgenstein's cryptic proposal that a sensation is ‘not a something, but not a nothing either’ (PI 304). Instead, McDowell embraces the opposed view on which every experience is a ‘perfectly good something’ (1998b: 283), something of one kind or another, for it must be possible to bring it under the appropriate concepts. What McDowell misses here, I believe, is that a central aim of Wittgenstein's discussion of our supposed ability to refer to inner objects is to attack the very idea of ‘pre-linguistic awareness … as a substratum on which the capacity for concept-carried awareness is constructed’ (ibid.). (shrink)

An examination of Helga Kuhse, Caring: Nurses, Women and Ethics (1997).

“Hildebrand has constructed a well-paced and historically informative evaluation of neopragmatism. . . . This book makes an excellent companion for courses in both contemporary epistemology and American philosophy.” –Choice How faithful are the Neopragmatists' reformulations of Classical Pragmatism? Can their Neopragmatisms work? In examining the difficulties in Neopragmatism, David L. Hildebrand is able to propose some distinct directions for Pragmatism.

For a long time, several natural phenomena have been considered unproblematically selection processes in the same sense of “selection.” In our target article we dealt with three of these phenomena: gene-based selection in biological evolution, the reaction of the immune system to antigens, and operant learning. We characterize selection in terms of three processes (variation, replication, and environmental interaction) resulting in the evolution of lineages via differential replication. Our commentators were largely supportive with respect to variation and environmental interaction but (...) critical with respect to replication, in particular its appeal to information. With some reservations, our commentators think that our general analysis of selection may fit gene-based selection in biological evolution and the reaction of the immune system but not operant learning. If nothing else, this article shows that the notion of selection is not as straightforward as it may seem. (shrink)

Historians must have an understanding of the present both to reconstruct the past and to explain that reconstruction to a contemporary audience. One criticism of presentism is that it is an interpretation of the past in terms of current values and ideas, and fails to provide a complete picture of the historical context. Regardless of such practices, however, the historian is limited to the methodological and archival tools available during his own time. Meaning, reason, and truth are different for different (...) periods and peoples. The clarity of his language, the consistency of his logic, and the validity of his proofs are relative to the historian's time and culture. The act of historical inquiry is influenced by the contrasts between past and present. Only by consciously addressing his dependence on the present can the historian adequately understand the past. (shrink)

According to the somatic mutation theory (SMT), cancer begins with a genetic change in a single cell that passes it on to its progeny, thereby generating a clone of malignant cells. It is strongly supported by observations of leukemias that bear specific chromosome translocations, such as Burkitt's lymphoma, in which a translocation activates the c‐myc gene, and chronic myeloid leukemia (CML), in which the Philadelphia chromosome causes production of the BCR‐ABL oncoprotein. Although the SMT has been modified and extended to (...) encompass tumor suppressor genes, epigenetic inheritance, and tumor progression through accumulation of further mutations, perhaps the strongest validation comes from the successful treatment of certain malignancies with drugs that directly target the product of the mutant gene.magnified imageDavid Vaux is at the Walter and Eliza Hall Institute and La Trobe Institute for Molecular Science, Melbourne, Australia. (shrink)

An invisible hand seems to play an important role in science. In this paper I set out the general structure of invisible-hand explanations, counter some objections that have been raised to them, and detail the role that they play in science. The most important issue is the character of the mechanisms that are supposed to bring about invisible-hand effects.

I argue that the numbering system of the Tractatus lets us see how it was constructed, in two closely related senses of that term. First, it tells us a great deal about the genesis of the book, for the numbering system was used to assemble and rearrange a series of drafts, as recorded in MS 104. Second, it helps us understand the structure of the published book, as cryptically summarized in the opening footnote. I also discuss an unpublished letter from (...) Anscombe to von Wright from 1948 which contains the very first sketch of a tree-structured reading, and what I believe is Stenius’s response to Anscombe’s proposal. The paper critically evaluates previous work on tree-structured readings and contends that we need to read the Tractatus in both the number order used in the published book and the tree order that Wittgenstein used to draft it. It also considers some of the main ways of turning this complex branching structure into a linear, printed text, and so serves as an introduction to the three tree-structured editions of the Tractatus that accompany this paper (the German text, and the translations by Ogden/Ramsey and Pears & McGuinness). (shrink)

A belief common among philosophers and biologists alike is that Mendelian genetics has been or is in the process of being reduced to molecular genetics, in the sense of formal theory reduction current in the literature. The purpose of this paper is to show that there are numerous empirical and conceptual difficulties which stand in the way of establishing a systematic inferential relation between Mendelian and molecular genetics. These difficulties, however, have little to do with the traditional objections which have (...) been raised to reduction. (shrink)

Quentin Skinner’s appropriation of speech act theory for intellectual history has been extremely influential. Even as the model continues to be important for historians, however, philosophers now regard the original speech act theory paradigm as dated. Are there more recent initiatives that might reignite theoretical work in this area? This article argues that the inferentialism of Robert Brandom is one of the most interesting contemporary philosophical projects with historical implications. It shows how Brandom’s work emerged out of the broad shift (...) in the philosophy of language from semantics to pragmatics that also informed speech act theory. The article then goes on to unpack the rich implications of Brandom’s inferentialism for the theory and practice of intellectual history. It contends that inferentialism clarifies, legitimizes, and informs intellectual historical practice, and it concludes with a consideration of the challenges faced by inferentialist intellectual history, together with an argument for the broader implications of Brandom’s work. (shrink)

Individuals with autistic spectrum disorder (ASD) display diverse deficits in social, cognitive and behavioral functioning. To date, there has been mixed findings on the profile of executive function deficits for high-functioning adults (IQ >70) with ASD. A conceptual distinction is commonly made between “cold” and “hot” executive functions. Cold executive functions refer to mechanistic higher-order cognitive operations (e.g., working memory), whereas hot executive functions entail cognitive abilities supported by emotional awareness and social perception (e.g., social cognition). This study aimed to (...) determine the independence of deficits in hot and cold executive functions for high-functioning adults with ASD. Forty-two adults with ASD (64% male, aged 18-66 years) and 40 age and gender matched controls were administered The Awareness of Social Inference Test (TASIT; emotion recognition and social inference), Letter Number Sequencing (working memory) and Hayling Sentence Completion Test (response initiation and suppression). Between-group analyses identified that the ASD group performed significantly worse than matched controls on all measures of cold and hot executive functions (d =.54-1.5). Hierarchical multiple regression analyses revealed that the ASD sample performed more poorly on emotion recognition and social inference tasks than matched controls after controlling for cold executive functions and employment status. The findings also indicated that the ability to recognise emotions and make social inferences was supported by working memory and response initiation and suppression processes. Overall, this study supports the distinction between hot and cold executive function impairments for adults with ASD. Moreover, it advances understanding of higher-order impairments underlying social interaction difficulties for this population which, in turn, may assist with diagnosis and inform intervention programs. (shrink)

No verão de 1932, Wittgenstein alegou que o artigo recentemente publicado porCarnap “Linguagem Física como Linguagem Universal da Ciência” fez uso extensivo e semmenções das idéias do próprio Wittgenstein. Em uma carta a Schlick, ele se queixou que“em breve estaria em uma situação na qual seu próprio trabalho seria considerado meramentecomo uma versão requentada ou plágio do de Carnap”. Neste artigo, examino arelação entre o artigo de Carnap, posteriormente reimpresso como A Unidade da Ciência, eo tratamento dispensado por Wittgenstein, nos (...) primeiros sete capítulos das ObservaçõesFilosóficas e outros escritos entre 1929-1932, a assuntos relacionados. (shrink)

In 1929, Wittgenstein made use of river imagery to convey the supposedly inexpressible thesis that all is in flux. However, he rejects this extreme thesis in manuscripts from the early 1930s and drafts of the Philosophical Investigations, affirming that one can step twice into the same river. His later discussion of the “stream of life” involves a return, in certain respects, to the river analogy, albeit in a very different key. Examining Wittgenstein’s changing use of this image casts light on (...) the continuities and discontinuities in the development of his philosophy. Wittgenstein’s argument that a private definition is impossible because ostension always depends on a “technique of use”, and his rejection of a positive theory of mind is clarified by examining some unusually explicit notes for a public lecture on private language. This material shows how the treatment of training and practice in the opening sections of the Philosophical Investigations is the basis for the subsequent discussion of both rule-following and privacy. (shrink)

Wittgenstein's middle period work has been brought into the current debate on rule following and representation by Kripke and the Hintikkas. In my dissertation, I argue that approaches which aim at a consistent reconstruction of Wittgenstein's argument, while valuable in their own right, fail to do justice to his focus on the conflicting intuitions that lie behind philosophical theory building. For this hidden and ambiguous side to his thought is the turning point in his philosophical development. ;One can summarise my (...) findings as follows: In 1929, Wittgenstein recognised that the analysis of colour propositions forced him to give up the Tractarian doctrine that analysis must end in logically independent elementary propositions. From this point, his work branched out in two main directions. On the one hand, he worked on 'philosophical grammar': analyses of the rules we follow in talking about such matters as colour, visual experience, intention, time, memory and the philosophical subject. Here, the picture theory provided the basis for an account of how the mind represents the world. On the other hand, he also thought of language as a 'secondary' system, to be contrasted with direct apprehension of the 'primary' phenomena. This view, which is set out most fully in several chapters of an unpublished typescript , led to a seemingly inexpressible solipsism on which 'all is in flux.' The attempt to reconcile the two conceptions of the pictorial analogy--language as a system of representational conventions and experience as a direct presentation of the phenomena--ultimately led him to see the dangers in that analogy and thus to his later notion of a 'philosophical picture.'. (shrink)

Extreme variation in the meaning of the term “species” throughout the history of biology has often frustrated attempts of historians, philosophers and biologists to communicate with one another about the transition in biological thinking from the static species concept to the modern notion of evolving species. The most important change which has underlain all the other fluctuations in the meaning of the word “species” is the change from it denoting such metaphysical entities as essences, Forms or Natures to denoting classes (...) of individual organisms. Several authors have taken notice of the role of metaphysics in the work of particular biologists. An attempt will be made in this paper to present a systematic investigation of the role which metaphysics has played in the work of representative biologists throughout the history of biology, especially as it relates to their species concepts. (shrink)

Considered the most original thinker in the Italian philosophical tradition, Giambattista Vico has been the object of much scholarly attention but little consensus. In this new interpretation, David L. Marshall examines the entirety of Vico's oeuvre and situates him in the political context of early modern Naples. He demonstrates Vico's significance as a theorist who adapted the discipline of rhetoric to modern conditions. Marshall presents Vico's work as an effort to resolve a contradiction. As a professor of rhetoric at (...) the University of Naples, Vico had a deep investment in the explanatory power of classical rhetorical thought, especially that of Aristotle, Cicero, and Quintilian. Yet as a historian of the failure of Naples as a self-determining political community, he had no illusions about the possibility or worth of democratic and republican systems of government in the post-classical world. As Marshall demonstrates, by jettisoning the assumption that rhetoric only illuminates direct, face-to-face interactions between orator and auditor, Vico reinvented rhetoric for a modern world in which the Greek polis and the Roman res publica are no longer paradigmatic for political thought. (shrink)

The contours of the portrait of David contained in the Old Testament narratives can be recognized more clearly if they are seen in relation to a portrait composed in a medium other than words.

"The premise of the Jewish attitude toward illness is that living is sacred, that good health enables us to live a fully religious life, and that disease is an evil. Any effective therapy is permitted, even if it conflicts with Jewish law. To bring about healing is a responsibility not only of the person who is ill and of the professional caregivers, but also of the loved ones, and of the larger circle of family, friends, and community." "Illness and Health (...) in the Jewish Tradition is an anthology of traditional and modern Jewish writings that highlights these basic principles."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved. (shrink)